This is due to the deployment of modern high-speed, high-resolution detectors, the increased complexity and variety of crystallographic software, the use of extensive databases and high-performance computing. Nowadays, progress in the determination of three-dimensional macromolecular structures from diffraction images is achieved partly at the cost of increasing data volumes. 18 Servier Research Institute in Croissy-sur-Seine, 125 Chemin de Ronde, 78290 Croissy, France.17 Biological Sciences, Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom.16 Crystallographic Methods, Institute of Molecular Biology of Barcelona (IBMB-CSIC), Barcelona Science Park, Helix Building, Baldiri Reixac 15, 08028 Barcelona, Spain.15 Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom.14 York Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5DD, United Kingdom.13 Biosciences, University of Exeter, Stocker Road, Exeter EX4 4QD, United Kingdom.12 Structural Biology Science Technology Platform, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, United Kingdom.11 Newcastle University Biosciences Institute Medical School, Newcastle upon Tyne NE2 4AX, United Kingdom.
10 European Molecular Biology Laboratory, Hamburg Unit, Notkestrasse 85, 22607 Hamburg, Germany.9 School of Physics and Astronomy, University of Birmingham, Birmingham B15 2TT, United Kingdom.8 Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 7ZB, United Kingdom.7 Global Phasing Limited, Sheraton House, Castle Park, Cambridge CB3 0AX, United Kingdom.6 Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77 Stockholm, Sweden.5 Institute of Protein Research, Pushchino 142290, Russian Federation.4 European Bioinformatics Institute, Hinxton CB9 1SD, United Kingdom.3 Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.2 Structural Studies Division, MRC Laboratory for Structural Biology, Cambridge CB2 0QH, United Kingdom.1 Scientific Computing Department, Science and Technology Facilities Council UK, Didcot OX11 0FA, United Kingdom.
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